pentobarbital will lower the level or impact of venetoclax by impacting hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will lessen the level or effect of vinorelbine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Unfamiliar.
pentobarbital will lower the level or result of imatinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Unfamiliar.
If unable to keep away from, double present-day pralsetinib dose beginning on Day 7 of coadministration with robust CYP3A inducer. Soon after inducer has long been discontinued for a minimum of fourteen times, resume former pralsetinib dose.
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pentobarbital will decrease the extent or impact of elagolix by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
pentobarbital will reduce the extent or outcome of lumefantrine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration with solid CYP3A4 inducers can result in diminished serum concentrations and lack of antimalarial efficacy
Reserve concomitant prescribing of these medication in patients for whom other therapy choices are inadequate. Restrict dosages and durations on the bare minimum necessary. Watch intently for indications of respiratory melancholy and sedation.
pentobarbital will reduce the extent or impact of etoposide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
With therapeutic doses of TCAs, barbiturates boost metabolism and decrease blood concentrations of TCAs.
pentobarbital will minimize the extent or result of tramadol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. Lessened AUC of tramadol plus the Energetic metabolite (O-desmethyltramadol) when coadministered with robust CYP3A4 and CYP2B6 inducers
Contraindicated (one)pentobarbital will minimize the level or impact of fostemsavir by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will lessen the extent or result of vinblastine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Unfamiliar.
Comment: Barbiturates may raise adverse results, together with respiratory melancholy, produced by poisonous doses 戊巴比妥鈉製作 of TCAs. With therapeutic doses of TCAs, barbiturates improve metabolism and reduce blood concentrations of TCAs.